General Information:

Id: 3,805 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HeLa cells, infected with C. burnetii NMII, producing BlaM-effector fusion proteins BlaM alone, BlaM-77, BlaM-1823, BlaM-1524
article
Reference: Newton HJ et al.(2013) Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole PLoS ONE 8 [PMID: 23349930]

Interaction Information:

Comment Translocation efficiencies for all three effector fusion proteins (CBU0077, CBU1823 and CBU1524 (caeA)) dropped significantly in cells where Rab5 or Rab7 had been silenced. Rab5 is known to interfere with early endosomal maturation events, Rab7 with late endosomal maturation events.
Formal Description
Interaction-ID: 37898

gene/protein

RAB5

increases_activity of

process

T4BSS

in C. burnetii infected HeLa cells