General Information:

Id: 3,805 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HeLa cells, infected with C. burnetii NMII, producing BlaM-effector fusion proteins BlaM alone, BlaM-77, BlaM-1823, BlaM-1524
article
Reference: Newton HJ et al.(2013) Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole PLoS ONE 8 [PMID: 23349930]

Interaction Information:

Comment Acidification of the Coxiella containing vacuole, CCV is required for Dot/Icm dependent effector translocation. Blocking the acidification of intracellular organelles with Bafilomycin A (BafA; 100 nM), a specific inhibitor of the vacuolar ATPase, results in no detectable translocation of any fusion protein detected after cells were infected for 24 hours.
Formal Description
Interaction-ID: 37877

increases_activity of

process

T4BSS

in C. burnetii infected HeLa cells