General Information:

Id: 3,805 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HeLa cells, infected with C. burnetii NMII, producing BlaM-effector fusion proteins BlaM alone, BlaM-77, BlaM-1823, BlaM-1524
article
Reference: Newton HJ et al.(2013) Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole PLoS ONE 8 [PMID: 23349930]

Interaction Information:

Comment Translocation of BlaM (reporter enzyme beta-lactamase) fused to the effector proteins CBU0077, CBU1823 and CBU1524 (caeA) of C. burnetii was not detected until 8-hours after infection of HeLa cells. This delay seems to be representative for the delivery of effectors by the Dot/Icm system of C. burnetii.
Formal Description
Interaction-ID: 37850

process

T4BSS

increases_transport of

gene/protein

CBU_0077

into HeLa cells; not detected before 8 hours post-infection, shown in a BlaM translocation assay