General Information:

Id: 3,774 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
THP-1 cells or Vero cells, infected with phase I or phase II C. burnetii
Reference: Voth DE and Heinzen RA(2009) Sustained activation of Akt and Erk1/2 is required for Coxiella burnetii antiapoptotic activity Infect. Immun. 77: 205-213 [PMID: 18981248]

Interaction Information:

Comment C. burnetii requires Akt and Erk1/2 activation to protect mammalian cells from staurosporine-induced death. Experiments done in THP-1 cells, infected with phase II C. burnetii for 48 h in the presence or absence of LY294002 (class I PI3K inhibitor) or U0126 (MEK1/2 inhibitor) and then treated with staurosporine for 4 or 8 h.
Formal Description
Interaction-ID: 36890

decreases_activity of


host cell apoptosis

in THP-1 cells; infected with C. burnetii phase II, cell death induced with stauroporine