General Information:

Id: 3,770 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
bone marrow-derived macrophages (BMDMs), infected with virulent/avirulent (phase I/phase II) C. burnetii or virulent/avirulent LPS (vLPS/avLPS)
article
Reference: Barry AO et al.(2012) Impaired Stimulation of p38alpha-MAPK/Vps41-HOPS by LPS from Pathogenic Coxiella burnetii Prevents Trafficking to Microbicidal Phagolysosomes Cell Host Microbe 12: 751-763 [PMID: 23245320]

Interaction Information:

Comment The results establish a critical role for p38alpha-MAPK signaling in C. burnetii fate and trafficking to lysosomes. avLPS (avirulent), but not vLPS (virulent), induces p38alpha-MAPK signaling, which drives endolysosomal conversion.
Formal Description
Interaction-ID: 36807

gene/protein

p38 MAPK

increases_activity of

in BMDMs and MEFs; infected with avirulent LPS