General Information:

Id: 3,770 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
bone marrow-derived macrophages (BMDMs), infected with virulent/avirulent (phase I/phase II) C. burnetii or virulent/avirulent LPS (vLPS/avLPS)
article
Reference: Barry AO et al.(2012) Impaired Stimulation of p38alpha-MAPK/Vps41-HOPS by LPS from Pathogenic Coxiella burnetii Prevents Trafficking to Microbicidal Phagolysosomes Cell Host Microbe 12: 751-763 [PMID: 23245320]

Interaction Information:

Comment The p38alpha-MAPK pathway-dependent trafficking of LPSs to lysosomes requires TLR4. TLR4 is required for vLPS (virulent) to inhibit p38a-MAPK phosphorylation.
Formal Description
Interaction-ID: 36806

gene/protein

TLR4

affects_activity of

gene/protein

p38 MAPK

in BMDMs; infected with virulent LPS
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