General Information:

Id: 3,770 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
bone marrow-derived macrophages (BMDMs), infected with virulent/avirulent (phase I/phase II) C. burnetii or virulent/avirulent LPS (vLPS/avLPS)
article
Reference: Barry AO et al.(2012) Impaired Stimulation of p38alpha-MAPK/Vps41-HOPS by LPS from Pathogenic Coxiella burnetii Prevents Trafficking to Microbicidal Phagolysosomes Cell Host Microbe 12: 751-763 [PMID: 23245320]

Interaction Information:

Comment Within a treatment of 30 min the authors analysed the absence of phosphorylated p38alpha-MAPK in BMDMs challenged with vLPS or vCb (virulent LPS or C. burnetii), in contrast to avLPS-or avCb (avirulent LPS or C. burnetii)-challenged BMDMs, in which phosphorylated p38a-MAPK could be detected. Thus p38alpha-MAPK can be defined as a key host factor differentially engaged during infection with avirulent and virulent strains of C. burnetii.
Formal Description
Interaction-ID: 36798

organism

Coxiella burnetii, phase I

NOT increases_phosphorylation of

gene/protein

p38 MAPK

in BMDMs; infected with virulent LPS or virulent C. burnetii