General Information:

Id: 3,724 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
CHO cells, infected with Dot/Icm-sufficient LP01 strain of L. pneumophila, expressing Cya fusions to the indicated C. burnetii proteins or HeLa cells expressing FLAG-tagged C. burnetii proteins
article
Reference: Carey KL et al.(2011) The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication PLoS Pathog. 7 [PMID: 21637816]

Interaction Information:

Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36193

process

T4BSS

increases_transport of

gene/protein

CBU_0077

into the host lysosomal membrane of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36200

process

T4BSS

increases_transport of

gene/protein

CBU_0080

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36202

process

T4BSS

increases_transport of

gene/protein

CBU_0295

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36204

process

T4BSS

increases_transport of

gene/protein

CBU_0329

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36207

process

T4BSS

increases_transport of

gene/protein

cirB

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36209

process

T4BSS

increases_transport of

gene/protein

CBU_0635

into the host cell Golgi vesicles of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36212

process

T4BSS

increases_transport of

gene/protein

CBU_1107

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36213

process

T4BSS

increases_transport of

gene/protein

CBU_1108

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36215

process

T4BSS

increases_transport of

gene/protein

caeA

into the host cell nucleus of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36217

process

T4BSS

increases_transport of

gene/protein

CBU_1525

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36218

process

T4BSS

increases_transport of

gene/protein

caeB

into the host cell mitochondria of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36219

process

T4BSS

increases_transport of

gene/protein

CBU_1776

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36220

process

T4BSS

increases_transport of

gene/protein

CBU_1823

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36221

process

T4BSS

increases_transport of

gene/protein

CBU_1825

into the host cell mitochondria of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36223

process

T4BSS

increases_transport of

gene/protein

CBU_1963

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36224

process

T4BSS

increases_transport of

gene/protein

cirD

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36226

process

T4BSS

increases_transport of

gene/protein

CBU_2056

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
Comment The authors identified 18 different C. burnetii proteins that are effectors delivered into host cells by the L. pneumophila Dot/Icm apparatus.
Formal Description
Interaction-ID: 36227

process

T4BSS

increases_transport of

gene/protein

cirE

into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus