General Information:

Id: 3,711 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HEK293 cells, CHO cells, HeLa cells infected with C. burnetii strain NMII
article
Reference: Klingenbeck L et al.The Coxiella burnetii type IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level [PMID: 23126667]

Interaction Information:

Comment The authors identified two T4SS effector proteins, named CaeA (CBU1524) and CaeB (CBU1532), that inhibit the intrinsic apoptotic pathway. The effector proteins were ectopically produced in transiently CHO cells, apoptosis measured after induction with staurosporine. CaeB blocks apoptosis very efficiently, while the anti-apoptotic activity of CaeA is weake.
Formal Description
Interaction-ID: 36071

gene/protein

caeA

decreases_activity of

process

host cell apoptosis

in CHO-FcR or HEK293 cells, transfected with GFP-tagged CaeA; to a lower extend than CaeB
Comment The authors identified two T4SS effector proteins, named CaeA (CBU1524) and CaeB (CBU1532), that inhibit the intrinsic apoptotic pathway. The effector proteins were ectopically produced in transiently CHO cells, apoptosis measured after induction with staurosporine. CaeB blocks apoptosis very efficiently, while the anti-apoptotic activity of CaeA is weaker.
Formal Description
Interaction-ID: 36073

gene/protein

caeB

decreases_activity of

process

host cell apoptosis

in CHO-FcR or HEK293 cells, transfected with GFP-tagged CaeB; to a higher extend than CaeA
Comment CaeB does not alter the steady-state level of the anti-apoptotic Bcl-2 like proteins Bcl-2, Bcl-X(L) and Mcl-1.
Formal Description
Interaction-ID: 36147

gene/protein

BCL2

decreases_activity of

process

host cell apoptosis

Drugbank entries Show/Hide entries for BCL2
Comment CaeB does not alter the steady-state level of the anti-apoptotic Bcl-2 like proteins Bcl-2, Bcl-X(L) and Mcl-1.
Formal Description
Interaction-ID: 36149

gene/protein

BCL2L1

decreases_activity of

process

host cell apoptosis

Drugbank entries Show/Hide entries for BCL2L1
Comment CaeB does not alter the steady-state level of the anti-apoptotic Bcl-2 like proteins Bcl-2, Bcl-X(L) and Mcl-1.
Formal Description
Interaction-ID: 36150

gene/protein

MCL1

decreases_activity of

process

host cell apoptosis

Comment Thereo were no obvious differences in the protein levels of the pro-apoptotic, BH3-only proteins Bim and Puma, while there was an upregulation of Bid in GFP-CaeB expressing HEK293 cells. There were no differences in the protein levels of Bak and Bax.
Formal Description
Interaction-ID: 36151

gene/protein

BCL2L11

increases_activity of

process

host cell apoptosis

Comment Thereo were no obvious differences in the protein levels of the pro-apoptotic, BH3-only proteins Bim and Puma, while there was an upregulation of Bid in GFP-CaeB expressing HEK293 cells. There were no differences in the protein levels of Bak and Bax.
Formal Description
Interaction-ID: 36153

gene/protein

BBC3

increases_activity of

process

host cell apoptosis

Comment Thereo were no obvious differences in the protein levels of the pro-apoptotic, BH3-only proteins Bim and Puma, while there was an upregulation of Bid in GFP-CaeB expressing HEK293 cells. There were no differences in the protein levels of Bak and Bax.
Formal Description
Interaction-ID: 36154

gene/protein

BAK1

increases_activity of

process

host cell apoptosis

Comment Thereo were no obvious differences in the protein levels of the pro-apoptotic, BH3-only proteins Bim and Puma, while there was an upregulation of Bid in GFP-CaeB expressing HEK293 cells. There were no differences in the protein levels of Bak and Bax.
Formal Description
Interaction-ID: 36156

gene/protein

BAX

increases_activity of

process

host cell apoptosis

Comment Thereo were no obvious differences in the protein levels of the pro-apoptotic, BH3-only proteins Bim and Puma, while there was an upregulation of Bid in GFP-CaeB expressing HEK293 cells. There were no differences in the protein levels of Bak and Bax.
Formal Description
Interaction-ID: 36158

gene/protein

BID

increases_activity of

process

host cell apoptosis