General Information:

Id: 3,711 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HEK293 cells, CHO cells, HeLa cells infected with C. burnetii strain NMII
article
Reference: Klingenbeck L et al.The Coxiella burnetii type IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level [PMID: 23126667]

Interaction Information:

Comment The authors identified two T4SS effector proteins, named CaeA (CBU1524) and CaeB (CBU1532), that inhibit the intrinsic apoptotic pathway. The effector proteins were ectopically produced in transiently CHO cells, apoptosis measured after induction with staurosporine. CaeB blocks apoptosis very efficiently, while the anti-apoptotic activity of CaeA is weake.
Formal Description
Interaction-ID: 36071

gene/protein

caeA

decreases_activity of

process

host cell apoptosis

in CHO-FcR or HEK293 cells, transfected with GFP-tagged CaeA; to a lower extend than CaeB