General Information:

Id: 3,707 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Hussain SK and Voth DE(2012) Coxiella subversion of intracellular host signaling Adv. Exp. Med. Biol. 984: 131-140 [PMID: 22711630]

Interaction Information:

Comment C. burnetii actively inhibits apoptotic cell death and activates the pro-survival kinases Akt and Erk1/2 to promote host viability.
Formal Description
Interaction-ID: 35953

process

Coxiella burnetii infection

decreases_activity of

process

host cell apoptosis

Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells.
Formal Description
Interaction-ID: 35964

gene/protein

CASP3

increases_activity of

process

host cell apoptosis

Drugbank entries Show/Hide entries for CASP3
Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells.
Formal Description
Interaction-ID: 35965

gene/protein

CASP9

increases_activity of

process

host cell apoptosis

Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells.
Formal Description
Interaction-ID: 35966

gene/protein

PARP1

increases_activity of

process

host cell apoptosis

Drugbank entries Show/Hide entries for PARP1
Comment Coxiella exhibits anti-apoptotic activity via inhibition of mitochondrial cytochrome c release in HeLa and CHO cells via inhibition of mitochondrial cytochrome c release.
Formal Description
Interaction-ID: 35969

increases_activity of

process

host cell apoptosis

in HeLa and CHO cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35973

gene/protein

BIRC3

decreases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35977

gene/protein

BCL2A1

decreases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35980

gene/protein

BAG1

decreases_activity of

process

host cell apoptosis

Drugbank entries Show/Hide entries for BAG1
Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35993

gene/protein

BAX

increases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35994

gene/protein

BCL2L11

increases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35995

gene/protein

BIK

increases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35996

gene/protein

CASP2

increases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35997

gene/protein

CASP6

increases_activity of

process

host cell apoptosis

Comment C. burnetii actively promotes activation of Akt and Erk1/2. Elevated phosphorylation levels are not observed in cells infected in the presence of bacterial protein synthesis inhibitors. Thus Akt and Erk1/2 are heavily involved in maintaining a viable eukaryotic cell via phosphorylation. Treatment of infected cells with Akt and Erk1/2 pathway inhibitors negates Coxiella's anti-apoptotic effec.
Formal Description
Interaction-ID: 36013

decreases_activity of

process

host cell apoptosis

induced by C. burnetii infection
Comment C. burnetii actively promotes activation of Akt and Erk1/2. Elevated phosphorylation levels are not observed in cells infected in the presence of bacterial protein synthesis inhibitors. Thus Akt and Erk1/2 are heavily involved in maintaining a viable eukaryotic cell via phosphorylation. Treatment of infected cells with Akt and Erk1/2 pathway inhibitors negates Coxiella's anti-apoptotic effec.
Formal Description
Interaction-ID: 36025

decreases_activity of

process

host cell apoptosis

induced by C. burnetii infection