General Information:

Id: 3,707 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
Reference: Hussain SK and Voth DE(2012) Coxiella subversion of intracellular host signaling Adv. Exp. Med. Biol. 984: 131-140 [PMID: 22711630]

Interaction Information:

Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells. Caspase-3 activation is also inhibited in primary primate alveolar macrophages, a Coxiella target cell.
Formal Description
Interaction-ID: 35958


Coxiella burnetii infection

decreases_processing of



in THP-1 macrophage-like cells
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