General Information:

Id: 3,707
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Hussain SK and Voth DE(2012) Coxiella subversion of intracellular host signaling Adv. Exp. Med. Biol. 984: 131-140 [PMID: 22711630]

Interaction Information:

Comment C. burnetii actively inhibits apoptotic cell death and activates the pro-survival kinases Akt and Erk1/2 to promote host viability.
Formal Description
Interaction-ID: 35953

process

Coxiella burnetii infection

decreases_activity of

process

host cell apoptosis

Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells. Caspase-3 activation is also inhibited in primary primate alveolar macrophages, a Coxiella target cell.
Formal Description
Interaction-ID: 35958

process

Coxiella burnetii infection

decreases_processing of

gene/protein

CASP3

in THP-1 macrophage-like cells
Drugbank entries Show/Hide entries for CASP3
Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells.
Formal Description
Interaction-ID: 35959

process

Coxiella burnetii infection

decreases_processing of

gene/protein

CASP9

in THP-1 macrophage-like cells
Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells.
Formal Description
Interaction-ID: 35960

process

Coxiella burnetii infection

decreases_processing of

gene/protein

PARP1

in THP-1 macrophage-like cells
Drugbank entries Show/Hide entries for PARP1
Comment Coxiella exhibits anti-apoptotic activity via inhibition of mitochondrial cytochrome c release in HeLa and CHO cells via inhibition of mitochondrial cytochrome c release.
Formal Description
Interaction-ID: 35962

process

Coxiella burnetii infection

decreases_activity of

in HeLa and CHO cells
Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells.
Formal Description
Interaction-ID: 35964

gene/protein

CASP3

increases_activity of

process

host cell apoptosis

Drugbank entries Show/Hide entries for CASP3
Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells.
Formal Description
Interaction-ID: 35965

gene/protein

CASP9

increases_activity of

process

host cell apoptosis

Comment C. burnetii antagonizes caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP) processing in response to staurosporine (intrinsic apoptosis) or TNF- (extrinsic apoptosis) induced THP-1 macrophage-like cells.
Formal Description
Interaction-ID: 35966

gene/protein

PARP1

increases_activity of

process

host cell apoptosis

Drugbank entries Show/Hide entries for PARP1
Comment Coxiella exhibits anti-apoptotic activity via inhibition of mitochondrial cytochrome c release in HeLa and CHO cells via inhibition of mitochondrial cytochrome c release.
Formal Description
Interaction-ID: 35969

increases_activity of

process

host cell apoptosis

in HeLa and CHO cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35970

process

Coxiella burnetii infection

increases_expression of

gene/protein

BIRC3

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35972

process

Coxiella burnetii infection

increases_quantity of

gene/protein

BIRC3

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35973

gene/protein

BIRC3

decreases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35974

process

Coxiella burnetii infection

increases_expression of

gene/protein

BCL2A1

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35976

process

Coxiella burnetii infection

increases_quantity of

gene/protein

BCL2A1

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35977

gene/protein

BCL2A1

decreases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival.
Formal Description
Interaction-ID: 35979

process

Coxiella burnetii infection

increases_expression of

gene/protein

BAG1

in THP-1 cells
Drugbank entries Show/Hide entries for BAG1
Comment At the transcriptional level C. burnetii infected THP-1 cells show increased expression of cIAP2 (BIRC3), a1/bfl-1, and bag1, which promote survival. The protein level of cIAP2 and A1/Bfl-1 also dramatically increases during infection.
Formal Description
Interaction-ID: 35980

gene/protein

BAG1

decreases_activity of

process

host cell apoptosis

Drugbank entries Show/Hide entries for BAG1
Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35981

process

Coxiella burnetii infection

decreases_expression of

gene/protein

BAX

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35986

process

Coxiella burnetii infection

decreases_expression of

gene/protein

BCL2L11

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35988

process

Coxiella burnetii infection

decreases_expression of

gene/protein

BIK

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35990

process

Coxiella burnetii infection

decreases_expression of

gene/protein

CASP2

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35991

process

Coxiella burnetii infection

decreases_expression of

gene/protein

CASP6

in THP-1 cells
Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35993

gene/protein

BAX

increases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35994

gene/protein

BCL2L11

increases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35995

gene/protein

BIK

increases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35996

gene/protein

CASP2

increases_activity of

process

host cell apoptosis

Comment At the transcriptional level C. burnetii infected THP-1 cells show decreased expression of pro-apoptotic bax, bim, bik, casp2, and casp6, contributing to an overall anti-apoptotic state.
Formal Description
Interaction-ID: 35997

gene/protein

CASP6

increases_activity of

process

host cell apoptosis

Comment It has been shown that cIAP2 and a1/bfl-1 are regulated by NF-kappa-B transcriptional activity. NF-kappa-B translocates to the host nucleus during early stages of Coxiella infection and substantial nuclear levels persist throughout intracellular growth.
Formal Description
Interaction-ID: 36000

affects_expression of

gene/protein

BCL2A1

Comment It has been shown that cIAP2 and a1/bfl-1 are regulated by NF-kappa-B transcriptional activity. NF-kappa-B translocates to the host nucleus during early stages of Coxiella infection and substantial nuclear levels persist throughout intracellular growth.
Formal Description
Interaction-ID: 36002

affects_expression of

gene/protein

BIRC3

Comment During intracellular growth, the parasitophorous vacuole (PV) decorates with the autophagy-related protein Beclin-1 and the anti-apoptotic mitochondrial protein Bcl-2. The interaction between these two proteins is critical for both PV biogenesis and inhibition of apoptosis.
Formal Description
Interaction-ID: 36012

gene/protein

BECN1

interacts (colocalizes) with

gene/protein

BCL2

Drugbank entries Show/Hide entries for BCL2
Comment C. burnetii actively promotes activation of Akt and Erk1/2. Elevated phosphorylation levels are not observed in cells infected in the presence of bacterial protein synthesis inhibitors. Thus Akt and Erk1/2 are heavily involved in maintaining a viable eukaryotic cell via phosphorylation. Treatment of infected cells with Akt and Erk1/2 pathway inhibitors negates Coxiella's anti-apoptotic effec.
Formal Description
Interaction-ID: 36013

decreases_activity of

process

host cell apoptosis

induced by C. burnetii infection
Comment C. burnetii actively promotes activation of Akt and Erk1/2. Elevated phosphorylation levels are not observed in cells infected in the presence of bacterial protein synthesis inhibitors. Thus Akt and Erk1/2 are heavily involved in maintaining a viable eukaryotic cell via phosphorylation. Treatment of infected cells with Akt and Erk1/2 pathway inhibitors negates Coxiella's anti-apoptotic effec.
Formal Description
Interaction-ID: 36025

decreases_activity of

process

host cell apoptosis

induced by C. burnetii infection
Comment It has been shown that cIAP2 and a1/bfl-1 are regulated by NF-kappa-B transcriptional activity. NF-kappa-B translocates to the host nucleus during early stages of Coxiella infection and substantial nuclear levels persist throughout intracellular growth.
Formal Description
Interaction-ID: 36909

process

Coxiella burnetii infection

increases_activity of