General Information:

Id: 3,695 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Newton HJ and Roy CRThe Coxiella burnetii Dot/Icm system creates a comfortable home through lysosomal renovation [PMID: 22010216]

Interaction Information:

Comment The function of the Dot/Icm type IV secretion system (T4BSS) has been shown to be necessary for development of the large Coxiella-containing vacuole (CCV), productive intracellular replication, and apoptosis protection of infected THP-1 cells. These facts were supported by another study demonstrating that a transposon insertion in the C. burnetii icmL gene abolished effector translocation and intracellular replication of C. burnetii in mammalian cells.
Formal Description
Interaction-ID: 35651

process

T4BSS

increases_activity of

in THP-1 cells
Comment The function of the Dot/Icm type IV secretion system (T4BSS) has been shown to be necessary for development of the large Coxiella-containing vacuole (CCV), productive intracellular replication, and apoptosis protection of infected THP-1 cells. These facts were supported by another study demonstrating that a transposon insertion in the C. burnetii icmL gene abolished effector translocation and intracellular replication of C. burnetii in mammalian cells.
Formal Description
Interaction-ID: 35654

process

T4BSS

increases_activity of

process

Coxiella burnetii replication

in THP-1 cells
Comment The function of the Dot/Icm type IV secretion system (T4BSS) has been shown to be necessary for development of the large Coxiella-containing vacuole (CCV), productive intracellular replication, and apoptosis protection of infected THP-1 cells. These facts were supported by another study demonstrating that a transposon insertion in the C. burnetii icmL gene abolished effector translocation and intracellular replication of C. burnetii in mammalian cells.
Formal Description
Interaction-ID: 35656

process

T4BSS

decreases_activity of

process

host cell apoptosis

in THP-1 cells
Comment The function of the Dot/Icm type IV secretion system (T4BSS) is not required for axenic growth or uptake by host cells.
Formal Description
Interaction-ID: 35657

process

T4BSS

NOT affects_activity of

process

axenic cell growth

Comment The function of the Dot/Icm type IV secretion system (T4BSS) is not required for axenic growth or uptake by host cells.
Formal Description
Interaction-ID: 35659

process

T4BSS

NOT affects_activity of

of C. burnetii into host
Comment Developing the large-cell variants (LCV) by acidification is the stage where translocation of bacterial effector proteins into the host cell mediated by the Dot/Icm T4SS can be detected.
Formal Description
Interaction-ID: 35673

organism

Coxiella burnetii, LCV

increases_activity of

process

T4BSS