General Information:

Id: 3,695 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
Reference: Newton HJ and Roy CRThe Coxiella burnetii Dot/Icm system creates a comfortable home through lysosomal renovation [PMID: 22010216]

Interaction Information:

Comment The function of the Dot/Icm type IV secretion system (T4BSS) has been shown to be necessary for development of the large Coxiella-containing vacuole (CCV), productive intracellular replication, and apoptosis protection of infected THP-1 cells. These facts were supported by another study demonstrating that a transposon insertion in the C. burnetii icmL gene abolished effector translocation and intracellular replication of C. burnetii in mammalian cells.
Formal Description
Interaction-ID: 35654



increases_activity of


Coxiella burnetii replication

in THP-1 cells