General Information:

Id: 3,688
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Capo C and Mege JL(2012) Role of innate and adaptive immunity in the control of q Fever Adv. Exp. Med. Biol. 984: 273-286 [PMID: 22711637]

Interaction Information:

Comment IFN-gamma restores phagosome-lysosome fusion and affects phagosomal pH. This mechanism probably accounts for the restoration of phagosome-lysosome fusion in monocytes in patients with acute Q fever.
Formal Description
Interaction-ID: 35407

gene/protein

IFNG

increases_activity of

Drugbank entries Show/Hide entries for IFNG
Comment IFN-gamma restores phagosome-lysosome fusion and affects phagosomal pH. This mechanism probably accounts for the restoration of phagosome-lysosome fusion in monocytes in patients with acute Q fever.
Formal Description
Interaction-ID: 35409

gene/protein

IFNG

affects_activity of

Drugbank entries Show/Hide entries for IFNG
Comment The change of the phagosomal pH may have some therapeutic consequences, as demonstrated by the efficiency of the combination of doxycycline and chloroquine in the treatment of patients with chronic Q fever. This treatment promotes vacuolar alkalization and restores the in vitro bactericidal activity of antibiotics against C. burnetii.
Formal Description
Interaction-ID: 35411

drug/chemical compound

Doxycycline&Hydroxychloroquine

decreases_activity of

in patients with chronic Q fever
Comment IFN-gamma is able to promote the apoptosis of C. burnetii-infected macrophages.
Formal Description
Interaction-ID: 35419

gene/protein

IFNG

increases_activity of

process

host cell apoptosis

of C. burnetii-infected macrophages
Drugbank entries Show/Hide entries for IFNG
Comment IFN-gamma up-regulates TNF production and induces the expression of membrane TNF. Neutralizing TNF with specific antibodies prevents macrophage apoptosis and the eradication of C. burnetii.
Formal Description
Interaction-ID: 35425

gene/protein

IFNG

increases_quantity of

gene/protein

TNF

Drugbank entries Show/Hide entries for IFNG or TNF
Comment IFN-gamma up-regulates TNF production and induces the expression of membrane TNF. Neutralizing TNF with specific antibodies prevents macrophage apoptosis and the eradication of C. burnetii.
Formal Description
Interaction-ID: 35429

gene/protein

TNF

increases_activity of

process

host cell apoptosis

of C. burnetii-infected macrophages
Drugbank entries Show/Hide entries for TNF
Comment IFN-gamma up-regulates TNF production and induces the expression of membrane TNF. Neutralizing TNF with specific antibodies prevents macrophage apoptosis and the eradication of C. burnetii.
Formal Description
Interaction-ID: 35430

gene/protein

TNF

decreases_activity of

process

pathogen survival

of C. burnetii-infected macrophages
Drugbank entries Show/Hide entries for TNF
Comment IFN-gamma induces homotypic adherence of C. burnetii-infected macrophages, which depends on beta-2 integrins and CD54.
Formal Description
Interaction-ID: 35442

gene/protein

IFNG

increases_activity of

of C. burnetii-infected macrophages
Drugbank entries Show/Hide entries for IFNG
Comment C. burnetii up-regulates the expression of transferrin receptors in murine macrophage cell lines, leading to an increased cell iron content and bacterial burden.
Formal Description
Interaction-ID: 35451

process

Coxiella burnetii infection

increases_activity of

in murine macrophage cell lines
Comment The intracellular iron chelator, desferoxamine, suppresses the replication of C. burnetii.
Formal Description
Interaction-ID: 35463

drug/chemical compound

Deferoxamine

decreases_activity of

Drugbank entries Show/Hide entries for Deferoxamine
Comment The intracellular iron chelator, desferoxamine, suppresses the replication of C. burnetii.
Formal Description
Interaction-ID: 35468

drug/chemical compound

Deferoxamine

decreases_activity of

process

Coxiella burnetii replication

Drugbank entries Show/Hide entries for Deferoxamine
Comment Lymphocytes from patients with Q fever endocarditis do not proliferate in response to the C. burnetii antigen, in contrast to lymphocytes from patients with acute Q fever.
Formal Description
Interaction-ID: 35478

disease

Q fever, chronic

NOT increases_activity of

Comment Lymphocytes from patients with Q fever endocarditis do not proliferate in response to the C. burnetii antigen, in contrast to lymphocytes from patients with acute Q fever.
Formal Description
Interaction-ID: 35480

disease

Q fever, acute

increases_activity of

Comment Age is a risk factor for Q fever.
Formal Description
Interaction-ID: 35501

process

aging

increases_activity of

process

Coxiella burnetii infection

Comment Gender also affects C. burnetii infection. There is a predisposition for infection in men.
Formal Description
Interaction-ID: 35503

phenotype

gender

affects_activity of

process

Coxiella burnetii infection

Comment IFN-gamma induces homotypic adherence of C. burnetii-infected macrophages, which depends on beta-2 integrins and CD5.
Formal Description
Interaction-ID: 37828

complex/PPI

AlphaM-beta2 integrin complex

increases_activity of

of C. burnetii-infected macrophages