General Information:

Id: 3,683 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human bronchial epithelial cells, infected with P. aeruginosa strain PAO1
Reference: Gellatly SL et al.(2012) The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation Infect. Immun. 80: 3122-3131 [PMID: 22710876]

Interaction Information:

Comment Several virulence factors were downregulated in a phoQ mutant during interaction with human epithelial cells in vitro, based on qPCR analysis. Lipases lipA and lipC, as well as the lipase modulator lipH, which controls both LipA and LipC, were downregulated in the phoQ mutant by 3- to 5.7-fold.
Formal Description
Interaction-ID: 35366



increases_expression of



during adherence to HBE cells
Drugbank entries Show/Hide entries for phoQ or lipA