General Information:

Id: 3,683 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human bronchial epithelial cells, infected with P. aeruginosa strain PAO1
article
Reference: Gellatly SL et al.(2012) The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation Infect. Immun. 80: 3122-3131 [PMID: 22710876]

Interaction Information:

Comment Several virulence factors were downregulated in a phoQ mutant during interaction with human epithelial cells in vitro, based on qPCR analysis. Elastase B (lasB) showed the biggest difference from the WT, (26-fold-reduction).
Formal Description
Interaction-ID: 35362

gene/protein

phoQ

increases_expression of

gene/protein

lasB

during adherence to HBE cells
Drugbank entries Show/Hide entries for phoQ or lasB