human bronchial epithelial cells, infected with P. aeruginosa strain PAO1
Gellatly SL et al.(2012) The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation Infect. Immun. 80: 3122-3131
Several virulence factors were downregulated in a phoQ mutant during interaction with human epithelial cells in vitro, based on qPCR analysis. Elastase B (lasB) showed the biggest difference from the WT, (26-fold-reduction).
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