General Information:

Id: 3,668 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
B6 mice bone marrow dentritic cells (DCs) or CHO cells, infected with L. pneumophila delta-flaA expressing the pJV400 vector, AnkG of C. burnetii
article
Reference: Luhrmann A et al.(2010) Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein Proc. Natl. Acad. Sci. U.S.A. 107 [PMID: 20944063]

Interaction Information:

Comment AnkG delivered by the L. pneumophila Dot/Icm system is able to disrupt pathogen-induced apoptosis in dentritic cells (DCs) of mice.
Formal Description
Interaction-ID: 35102

gene/protein

ankG

decreases_activity of

process

host cell apoptosis

shown in dentritic cells of B6 mice
Comment Knock-down of gC1qR (p32) prevents L. pneumophila-induced apoptosis and allows bacterial intracellular replication in dentritic cells (DCs).
Formal Description
Interaction-ID: 35104

gene/protein

C1QBP

increases_activity of

process

host cell apoptosis

shown in dentritic cells of B6 mice