General Information:

Id: 3,666 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
CHo cells, HEK 293 cells, transfected with C. burnetii ankG;
article
Reference: Luhrmann A et al.(2010) Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein Proc. Natl. Acad. Sci. U.S.A. 107 [PMID: 20944063]

Interaction Information:

Comment In CHO-FcR cells infected with L. pneumophila that produced the C. burnetii AnkG protein, AnkG was sufficient to block staurosporine-induced apoptosis. The amino terminal AnkG region (1-69) has been analysed as domain that is both necessary and sufficient for inhibition of apoptosis and gC1qR (p32) interaction, as shown in CHO and HEK 293 cells, expressing the Ha-tagged truncations of AnkG.
Formal Description
Interaction-ID: 35090

gene/protein

ankG

decreases_activity of

process

host cell apoptosis

shown in transfected CHO and HEK293 cells