General Information:

Id: 3,666 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
CHo cells, HEK 293 cells, transfected with C. burnetii ankG;
article
Reference: Luhrmann A et al.(2010) Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein Proc. Natl. Acad. Sci. U.S.A. 107 [PMID: 20944063]

Interaction Information:

Comment In CHO-FcR cells infected with L. pneumophila that produced the C. burnetii AnkG protein, AnkG was sufficient to block staurosporine-induced apoptosis. The amino terminal AnkG region (1-69) has been analysed as domain that is both necessary and sufficient for inhibition of apoptosis and gC1qR (p32) interaction, as shown in CHO and HEK 293 cells, expressing the Ha-tagged truncations of AnkG.
Formal Description
Interaction-ID: 35090

gene/protein

ankG

decreases_activity of

process

host cell apoptosis

shown in transfected CHO and HEK293 cells
Comment It has been described that reducing the levels of gC1qR (p32) in mammalian cells make them more resistant to apoptosis, suggesting that p32 has a proapoptotic activity.
Formal Description
Interaction-ID: 35092

gene/protein

C1QBP

increases_activity of

process

host cell apoptosis