General Information:

Id: 3,660
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Benoit M et al.(2008) Macrophage polarization in bacterial infections J. Immunol. 181: 3733-3739 [PMID: 18768823]

Interaction Information:

Comment Coxiella burnetii is an obligate intracellular bacterium that causes Q fever, an acute disease with a risk of chronic evolution.
Formal Description
Interaction-ID: 34903

process

Coxiella burnetii infection

increases_activity of

disease

Q fever, acute

Comment Coxiella burnetii is an obligate intracellular bacterium that causes Q fever, an acute disease with a risk of chronic evolution.
Formal Description
Interaction-ID: 34908

process

Coxiella burnetii infection

increases_activity of

disease

Q fever, chronic

Comment The response of C. burnetii infection exhibits an M1 program in monocytes and an atypical M2 profile in macrophages combining M1/M2 characteristics.
Formal Description
Interaction-ID: 34910

increases_activity of

process

M1 polarization

in response to C. burnetii infection
Comment The response of C. burnetii infection exhibits an M1 program in monocytes and an atypical M2 profile in macrophages combining M1/M2 characteristics.
Formal Description
Interaction-ID: 34912

increases_activity of

process

atypical M2 polarization

in response to C. burnetii infection
Comment The response of C. burnetii infection exhibits an M1 program in monocytes that control bacterial replication.
Formal Description
Interaction-ID: 34914

disease

Q fever, acute

increases_activity of

process

M1 polarization

in monocytes
Comment The response of C. burnetii infection exhibits an atypical M2 program in macrophages. M2 macrophages are unable to control C. burnetii replication, as observed during acute Q fever.
Formal Description
Interaction-ID: 34916

disease

Q fever, acute

increases_activity of

process

atypical M2 polarization

in macrophages
Comment C. burnetii-infected macrophages release the M2-associated molecules IL-10, TGF-beta-1, and CCL18 and express mannose receptor and the active form of arginase-1.
Formal Description
Interaction-ID: 34921

process

atypical M2 polarization

increases_quantity of

gene/protein

IL10

in macrophages; in response to C. burnetii infection
Comment C. burnetii-infected macrophages release the M2-associated molecules IL-10, TGF-beta-1, and CCL18 and express mannose receptor and the active form of arginase-1.
Formal Description
Interaction-ID: 34922

process

atypical M2 polarization

increases_quantity of

gene/protein

TGFB1

in macrophages; in response to C. burnetii infection
Drugbank entries Show/Hide entries for TGFB1
Comment C. burnetii-infected macrophages release the M2-associated molecules IL-10, TGF-beta-1, and CCL18 and express mannose receptor and the active form of arginase-1.
Formal Description
Interaction-ID: 34923

process

atypical M2 polarization

increases_quantity of

gene/protein

CCL18

in macrophages; in response to C. burnetii infection
Comment C. burnetii-infected macrophages release the M2-associated molecules IL-10, TGF-beta-1, and CCL18 and express mannose receptor and the active form of arginase-1.
Formal Description
Interaction-ID: 34924

process

atypical M2 polarization

increases_quantity of

gene/protein

MRC1

in macrophages; in response to C. burnetii infection
Comment C. burnetii-infected macrophages release the M2-associated molecules IL-10, TGF-beta-1, and CCL18 and express mannose receptor and the active form of arginase-1.
Formal Description
Interaction-ID: 34925

process

atypical M2 polarization

increases_quantity of

gene/protein

ARG1

in macrophages; in response to C. burnetii infection
Drugbank entries Show/Hide entries for ARG1
Comment C. burnetii-infected macrophages release high levels of IL-6 and CXCL8, two molecules associated with M1 polarization.
Formal Description
Interaction-ID: 34926

process

atypical M2 polarization

increases_quantity of

gene/protein

IL6

in macrophages; in response to C. burnetii infection
Drugbank entries Show/Hide entries for IL6
Comment C. burnetii-infected macrophages release high levels of IL-6 and CXCL8, two molecules associated with M1 polarization.
Formal Description
Interaction-ID: 34927

process

atypical M2 polarization

increases_quantity of

gene/protein

CXCL8

in macrophages; in response to C. burnetii infection
Comment C. burnetii-infected macrophages do not express other M1 molecules such as TNF, IL-12, CD80, and CCR7, and they fail to produce NO.
Formal Description
Interaction-ID: 34928

process

atypical M2 polarization

NOT increases_quantity of

gene/protein

TNF

in macrophages; in response to C. burnetii infection
Drugbank entries Show/Hide entries for TNF
Comment C. burnetii-infected macrophages do not express other M1 molecules such as TNF, IL-12, CD80, and CCR7, and they fail to produce NO.
Formal Description
Interaction-ID: 34931

process

atypical M2 polarization

NOT increases_quantity of

gene/protein

IL12

in macrophages; in response to C. burnetii infection
Comment C. burnetii-infected macrophages do not express other M1 molecules such as TNF, IL-12, CD80, and CCR7, and they fail to produce NO.
Formal Description
Interaction-ID: 34932

process

atypical M2 polarization

NOT increases_quantity of

gene/protein

CD80

in macrophages; in response to C. burnetii infection
Drugbank entries Show/Hide entries for CD80
Comment C. burnetii-infected macrophages do not express other M1 molecules such as TNF, IL-12, CD80, and CCR7, and they fail to produce NO.
Formal Description
Interaction-ID: 34933

process

atypical M2 polarization

NOT increases_quantity of

gene/protein

CCR7

in macrophages; in response to C. burnetii infection
Comment C. burnetii-infected macrophages do not express other M1 molecules such as TNF, IL-12, CD80, and CCR7, and they fail to produce NO.
Formal Description
Interaction-ID: 34934

process

atypical M2 polarization

NOT increases_quantity of

drug/chemical compound

Reactive nitrogen species

in macrophages; in response to C. burnetii infection
Comment C. burnetii induces an atypical M2 profile in macrophages. M2 macrophages are unable to control C. burnetii replication, as observed during acute Q fever.
Formal Description
Interaction-ID: 34935

process

atypical M2 polarization

NOT decreases_activity of

process

Coxiella burnetii replication

in macrophages; during acute Q fever
Comment The response of C. burnetii infection exhibits an M1 program in monocytes. The following molecules are secreted: CCR7, TNF, IL-6, IL-12, IFN-gamma.
Formal Description
Interaction-ID: 34936

process

M1 polarization

increases_quantity of

gene/protein

TNF

in monocytes; in response to C. burnetii infection
Drugbank entries Show/Hide entries for TNF
Comment The response of C. burnetii infection exhibits an M1 program in monocytes. The following molecules are secreted: CCR7, TNF, IL-6, IL-12, IFN-gamma.
Formal Description
Interaction-ID: 34937

process

M1 polarization

increases_quantity of

gene/protein

IL6

in monocytes; in response to C. burnetii infection
Drugbank entries Show/Hide entries for IL6
Comment The response of C. burnetii infection exhibits an M1 program in monocytes. The following molecules are secreted: CCR7, TNF, IL-6, IL-12, IFN-gamma.
Formal Description
Interaction-ID: 34938

process

M1 polarization

increases_quantity of

gene/protein

IL12

in monocytes; in response to C. burnetii infection
Comment The response of C. burnetii infection exhibits an M1 program in monocytes. The following molecules are secreted: CCR7, TNF, IL-6, IL-12, IFN-gamma.
Formal Description
Interaction-ID: 34939

process

M1 polarization

increases_quantity of

gene/protein

CCR7

in monocytes; in response to C. burnetii infection
Comment The response of C. burnetii infection exhibits an M1 program in monocytes. The following molecules are secreted: CCR7, TNF, IL-6, IL-12, IFN-gamma.
Formal Description
Interaction-ID: 34940

process

M1 polarization

increases_quantity of

gene/protein

IFNG

in monocytes; in response to C. burnetii infection
Drugbank entries Show/Hide entries for IFNG
Comment Monocytes from patients with Q fever endocarditis overproduce IL-10.
Formal Description
Interaction-ID: 34941

disease

Q fever, chronic

increases_quantity of

gene/protein

IL10

in monocytes; in response to C. burnetii infection
Comment In the presence of M2 cytokines such as IL-10 or following the ingestion of apoptotic cells, C. burnetii-infected monocytes and macrophages are polarized toward M2 cells, thus allowing for intense bacterial replication. This may be observed during the chronic evolution of Q fever.
Formal Description
Interaction-ID: 34942

disease

Q fever, chronic

increases_activity of

process

M2 polarization

in monocytes and macrophages
Comment In the presence of M2 cytokines such as IL-10 or following the ingestion of apoptotic cells, C. burnetii-infected monocytes and macrophages are polarized toward M2 cells, thus allowing for intense bacterial replication. This may be observed during the chronic evolution of Q fever.
Formal Description
Interaction-ID: 34943

increases_activity of

process

M2 polarization

associated to Q fever, chronic
Comment In the presence of M2 cytokines such as IL-10 or following the ingestion of apoptotic cells, C. burnetii-infected monocytes and macrophages are polarized toward M2 cells, thus allowing for intense bacterial replication. This may be observed during the chronic evolution of Q fever.
Formal Description
Interaction-ID: 34944

increases_activity of

process

M2 polarization

associated to Q fever, chronic
Comment The uptake of apoptotic cells by monocytes and macrophages is critical for chronic evolution of Q fever.
Formal Description
Interaction-ID: 34945

disease

Q fever, chronic

increases_activity of

Comment In the presence of M2 cytokines such as IL-10 or following the ingestion of apoptotic cells, C. burnetii-infected monocytes and macrophages are polarized toward M2 cells, thus allowing for intense bacterial replication. This may be observed during the chronic evolution of Q fever.
Formal Description
Interaction-ID: 34946

increases_activity of

process

M2 polarization

in monocytes and macrophages; associated to Q fever, chronic
Comment In monocytes, the ingestion of apoptotic cells induces a program characterized by the up-regulation of IL-10, IL-19, IL-20, IL-24, IL-1ra, CCL18, and CCL24.
Formal Description
Interaction-ID: 34948

process

M2 polarization

increases_quantity of

gene/protein

IL10

in monocytes; associated to Q fever, chronic
Comment In monocytes, the ingestion of apoptotic cells induces a program characterized by the up-regulation of IL-10, IL-19, IL-20, IL-24, IL-1ra, CCL18, and CCL24.
Formal Description
Interaction-ID: 34949

process

M2 polarization

increases_quantity of

gene/protein

IL19

in monocytes; associated to Q fever, chronic
Comment In monocytes, the ingestion of apoptotic cells induces a program characterized by the up-regulation of IL-10, IL-19, IL-20, IL-24, IL-1ra, CCL18, and CCL24.
Formal Description
Interaction-ID: 34950

process

M2 polarization

increases_quantity of

gene/protein

IL20

in monocytes; associated to Q fever, chronic
Comment In monocytes, the ingestion of apoptotic cells induces a program characterized by the up-regulation of IL-10, IL-19, IL-20, IL-24, IL-1ra, CCL18, and CCL24.
Formal Description
Interaction-ID: 34951

process

M2 polarization

increases_quantity of

gene/protein

IL24

in monocytes; associated to Q fever, chronic
Comment In monocytes, the ingestion of apoptotic cells induces a program characterized by the up-regulation of IL-10, IL-19, IL-20, IL-24, IL-1ra, CCL18, and CCL24.
Formal Description
Interaction-ID: 34952

process

M2 polarization

increases_quantity of

gene/protein

IL1RN

in monocytes; associated to Q fever, chronic
Comment In monocytes, the ingestion of apoptotic cells induces a program characterized by the up-regulation of IL-10, IL-19, IL-20, IL-24, IL-1ra, CCL18, and CCL24.
Formal Description
Interaction-ID: 34953

process

M2 polarization

increases_quantity of

gene/protein

CCL18

in monocytes; associated to Q fever, chronic
Comment In monocytes, the ingestion of apoptotic cells induces a program characterized by the up-regulation of IL-10, IL-19, IL-20, IL-24, IL-1ra, CCL18, and CCL24.
Formal Description
Interaction-ID: 34954

process

M2 polarization

increases_quantity of

gene/protein

CCL24

in monocytes; associated to Q fever, chronic
Comment In macrophages, the ingestion of apoptotic cells induces a program characterized by the up-regulation of CD14, TGF-beta-1, IL-1ra, IL-10, CCL16, and mannose receptor.
Formal Description
Interaction-ID: 34955

process

M2 polarization

increases_quantity of

gene/protein

CD14

in macrophages; associated to Q fever, chronic
Comment In macrophages, the ingestion of apoptotic cells induces a program characterized by the up-regulation of CD14, TGF-beta-1, IL-1ra, IL-10, CCL16, and mannose receptor.
Formal Description
Interaction-ID: 34956

process

M2 polarization

increases_quantity of

gene/protein

TGFB1

in macrophages; associated to Q fever, chronic
Drugbank entries Show/Hide entries for TGFB1
Comment In macrophages, the ingestion of apoptotic cells induces a program characterized by the up-regulation of CD14, TGF-beta-1, IL-1ra, IL-10, CCL16, and mannose receptor.
Formal Description
Interaction-ID: 34957

process

M2 polarization

increases_quantity of

gene/protein

IL1RN

in macrophages; associated to Q fever, chronic
Comment In macrophages, the ingestion of apoptotic cells induces a program characterized by the up-regulation of CD14, TGF-beta-1, IL-1ra, IL-10, CCL16, and mannose receptor.
Formal Description
Interaction-ID: 34958

process

M2 polarization

increases_quantity of

gene/protein

IL10

in macrophages; associated to Q fever, chronic
Comment In macrophages, the ingestion of apoptotic cells induces a program characterized by the up-regulation of CD14, TGF-beta-1, IL-1ra, IL-10, CCL16, and mannose receptor.
Formal Description
Interaction-ID: 34959

process

M2 polarization

increases_quantity of

gene/protein

CCL16

in macrophages; associated to Q fever, chronic
Comment The pattern of the M2 profile is associated with C. burnetii replication and accounts for chronic evolution of Q fever.
Formal Description
Interaction-ID: 34960

process

M2 polarization

increases_activity of

process

Coxiella burnetii replication

associated to Q fever, chronic
Comment The response of C. burnetii infection exhibits an M1 program in monocytes that control bacterial replication.
Formal Description
Interaction-ID: 34961

process

M1 polarization

decreases_activity of

process

Coxiella burnetii replication

in monocytes