General Information:

Id: 3,653 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Amara AB et al.(2012) Immune Response and Coxiella burnetii Invasion Adv. Exp. Med. Biol. 984: 287-298 [PMID: 22711638]

Interaction Information:

Comment C. burnetii infection of macrophages inhibits cell apoptosis via the upregulation of c/IAP2 (BIRC3) and A1/bfl1 (BCL2A1), which prevents the activation of caspase 3 and the BH3-only proteins.
Formal Description
Interaction-ID: 34846

gene/protein

BIRC3

decreases_activity of

process

host cell apoptosis

in macrophages