General Information:

Id: 3,653 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Amara AB et al.(2012) Immune Response and Coxiella burnetii Invasion Adv. Exp. Med. Biol. 984: 287-298 [PMID: 22711638]

Interaction Information:

Comment The activation state of monocytes and macrophages after encountering C. burnetii are apparently different.
Formal Description
Interaction-ID: 34756

process

Coxiella burnetii infection

increases_activity of

Comment The activation state of monocytes and macrophages after encountering C. burnetii are apparently different.
Formal Description
Interaction-ID: 34757

process

Coxiella burnetii infection

increases_activity of

Comment In addition to bone marrow cells, adipose tissue is a candidate to house C. burnetii. Adipose tissue macrophages are the probable targets of C. burnetii but adipocytes may also harbor C. burnetii.
Formal Description
Interaction-ID: 34794

process

Coxiella burnetii infection

is localized in

tissue/cell line

adipose tissue

Comment C. burnetii has been shown to be present in placenta.
Formal Description
Interaction-ID: 34801

process

Coxiella burnetii infection

is localized in

tissue/cell line

placenta

Comment C. burnetii infection of macrophages inhibits cell apoptosis via the upregulation of c/IAP2 (BIRC3) and A1/bfl1 (BCL2A1), which prevents the activation of caspase 3 and the BH3-only proteins.
Formal Description
Interaction-ID: 34842

process

Coxiella burnetii infection

decreases_activity of

process

host cell apoptosis

in macrophages
Comment C. burnetii infection of macrophages inhibits cell apoptosis via the upregulation of c/IAP2 (BIRC3) and A1/bfl1 (BCL2A1), which prevents the activation of caspase 3 and the BH3-only proteins.
Formal Description
Interaction-ID: 34843

process

Coxiella burnetii infection

increases_quantity of

gene/protein

BCL2A1

in macrophages
Comment C. burnetii infection of macrophages inhibits cell apoptosis via the upregulation of c/IAP2 (BIRC3) and A1/bfl1 (BCL2A1), which prevents the activation of caspase 3 and the BH3-only proteins.
Formal Description
Interaction-ID: 34844

process

Coxiella burnetii infection

increases_quantity of

gene/protein

BIRC3

in macrophages