General Information:

Id: 3,653 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Amara AB et al.(2012) Immune Response and Coxiella burnetii Invasion Adv. Exp. Med. Biol. 984: 287-298 [PMID: 22711638]

Interaction Information:

Comment In circulating monocytes, C. burnetii stimulates an M1-type activation that controls bacterial replication. The M1-type activation is associated with the release of: TNF, IL-6, IL-12, CD80, CCR7, IFN-gamma and NO production.
Formal Description
Interaction-ID: 34773

process

M1 polarization

increases_quantity of

gene/protein

TNF

in monocytes; in response to C. burnetii infection
Drugbank entries Show/Hide entries for TNF
Comment There is no expression of the M1 typical molecules TNF, IL-12, CD80 and CCR7 in macrophages in response to C. burnetii infection.
Formal Description
Interaction-ID: 34788

process

atypical M2 polarization

NOT increases_quantity of

gene/protein

TNF

in macrophages; in response to C. burnetii infection
Drugbank entries Show/Hide entries for TNF
Comment IL-10 decreases the TNF production, because TNF was shown to restore the microbicidal activity against C. burnetii in IL-10-treated monocytes.
Formal Description
Interaction-ID: 34813

gene/protein

IL10

decreases_quantity of

gene/protein

TNF

in monocytes
Drugbank entries Show/Hide entries for TNF