General Information:

Id: 3,598 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Gilk SD(2012) Role of Lipids in Coxiella burnetii Infection Adv. Exp. Med. Biol. 984: 199-213 [PMID: 22711633]

Interaction Information:

Comment C. burnetii-infected cells show 70% more total cholesterol than uninfected cells.
Formal Description
Interaction-ID: 33759

process

Coxiella burnetii infection

increases_quantity of

drug/chemical compound

host cell cholesterol

Comment C. burnetii-infected cells show a significant upregulation of genes involved in both host cell cholesterol biosynthesis and exogenous cholesterol uptake. Host low density lipoprotein (LDL) receptor and HMGCoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase are upregulated 4-5 days post infection.
Formal Description
Interaction-ID: 33760

process

Coxiella burnetii infection

increases_expression of

gene/protein

LDLR

4-5 days post infection
Drugbank entries Show/Hide entries for LDLR
Comment C. burnetii-infected cells show a significant upregulation of genes involved in both host cell cholesterol biosynthesis and exogenous cholesterol uptake. Host low density lipoprotein (LDL) receptor and HMGCoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase are upregulated 4-5 days post infection.
Formal Description
Interaction-ID: 33761

process

Coxiella burnetii infection

increases_expression of

gene/protein

HMGCR

4-5 days post infection
Drugbank entries Show/Hide entries for HMGCR