General Information:

Id: 3,596 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
mouse model of acute pneumonia
Reference: de Lima CD et al.(2012) ExoU Activates NF-kappaB and Increases IL-8/KC Secretion during Pseudomonas aeruginosa Infection PLoS ONE 7 [PMID: 22848596]

Interaction Information:

Comment ExoU induces NF-kappa-B-dependent KC (keratinocyte-derived cytokine) secretion and neutrophil infiltration in mice airways at 24 hours post-infection. Mice treated with the NF-kappa-B inhibitor Bay 11-7082 before infection revealed a significant reduction in KC secretion and neutrophil infiltration in bronchoalveolar lavage.
Formal Description
Interaction-ID: 33647



increases_quantity of


Keratinocyte-derived cytokine

in bronchoalveolar lavage fluids (BALF) in mice airways; analysed by ELISA