General Information:

Id: 3,595 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human epithelial respiratory and microvascular endothelial cell cultures, infected with P. aeruginosa strain PA103
article
Reference: de Lima CD et al.(2012) ExoU Activates NF-kappaB and Increases IL-8/KC Secretion during Pseudomonas aeruginosa Infection PLoS ONE 7 [PMID: 22848596]

Interaction Information:

Comment The phospholipase A2 (PLA2) activity of ExoU increases IL-8 mRNA and protein levels in P. aeruginosa-infected A549 airway epithelial and HMEC-1 microvascular endothelial cell lines. The cultures were infected for different periods of time by the ExoU-producing PA103 strain or its isogenic mutant, PA103 delta-exoU.
Formal Description
Interaction-ID: 33642

gene/protein

exoU

increases_expression of

gene/protein

CXCL8

in human epithelial respiratory and microvascular endothelial cell cultures; analysed by RT-PCR