General Information:

Id: 3,584
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PA14
article
Reference: Overhage J et al.(2008) Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance J. Bacteriol. 190: 2671-2679 [PMID: 18245294]

Interaction Information:

Comment The authors identified the two genes associated with virulence, pvdQ and lasB to play important roles in swarming behavior. Four independently derived lasB mutants showed strong swarming defects but normal swimming and twitching motility phenotypes compared to their corresponding wild-type strains.
Formal Description
Interaction-ID: 33538

gene/protein

lasB

increases_activity of

Drugbank entries Show/Hide entries for lasB
Comment The authors identified the two genes associated with virulence, pvdQ and lasB to play important roles in swarming behavior. The pvdQ mutant exhibits a strong swarming motility defect. The pvdQ gene was up-regulated threefold under swarming conditions.
Formal Description
Interaction-ID: 33546

gene/protein

pvdQ

increases_activity of

Comment The four tested lasB mutants showed a strong impairment in biofilm formation.
Formal Description
Interaction-ID: 33547

gene/protein

lasB

increases_activity of

Drugbank entries Show/Hide entries for lasB
Comment Swarmer cells exhibit enhanced antibiotic resistance.
Formal Description
Interaction-ID: 33558

increases_activity of

process

antibiotic resistance