General Information:

Id: 3,572 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HMDMs and THP-1 cells, infected with C. burnetii phase I variant (NMI) or phase II variant (NMII)
article
Reference: Howe D et al.(2010) Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages Infect. Immun. 78: 3465-3474 [PMID: 20515926]

Interaction Information:

Comment HMDMs (primary human monocyte-derived macrophages) infected with C. burnetii variants NMI and NMII secrete comparable levels of proinflammatory cytokines TNF-alpha and IL-6.
Formal Description
Interaction-ID: 33399

organism

Coxiella burnetii, phase II

increases_quantity of

gene/protein

TNF

in HMDM cells
Drugbank entries Show/Hide entries for TNF