General Information:

Id: 3,568 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
THP-1 cells, or HeLa cells, infected with avirulent C. burnetii phase II
article
Reference: Hussain SK et al.(2010) Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation Front Microbiol 1: 137 [PMID: 21772829]

Interaction Information:

Comment C. burnetii infection, using avirulent phase II organisms, causes differential phosphorylation of p38 and myosin light chain-2 (MLC-2), the downstream target of MLCK. The levels of phosphorylated p38 increased over those of uninfected cells at 2 hpi, then declined to near basal level between 48 and 72 hpi.
Formal Description
Interaction-ID: 33353

organism

Coxiella burnetii, phase II

increases_phosphorylation of

gene/protein

p38 MAPK

in THP-1 cells