General Information:

Id: 3,521 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: McDonough JA et al.(2012) Coxiella burnetii Secretion Systems Adv. Exp. Med. Biol. 984: 171-197 [PMID: 22711632]

Interaction Information:

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32721

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmW

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32739

process

Coxiella burnetii infection

increases_expression of

gene/protein

CBU_1651

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32741

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmX

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32743

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmV

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32744

process

Coxiella burnetii infection

increases_expression of

gene/protein

dotaA

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32745

process

Coxiella burnetii infection

increases_expression of

gene/protein

CBU_1647

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32748

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmT

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32749

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmS

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32750

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmD

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32752

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmC

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32753

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmB

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32755

process

Coxiella burnetii infection

increases_expression of

gene/protein

CBU_1646

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. The dot/icm locus is upregulated in response to infection.
Formal Description
Interaction-ID: 32756

process

Coxiella burnetii infection

increases_activity of

process

T4BSS

during the initial 16 h of infection
Comment RT-PCR analyses showed that the dot/icm genes, dotB, icmQ, icmS, and icmW are expressed during C. burnetii infection of Vero cells.
Formal Description
Interaction-ID: 32804

process

Coxiella burnetii infection

increases_expression of

gene/protein

dotB

in Vero cells
Comment RT-PCR analyses showed that the dot/icm genes, dotB, icmQ, icmS, and icmW are expressed during C. burnetii infection of Vero cells.
Formal Description
Interaction-ID: 32805

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmQ

in Vero cells
Comment RT-PCR analyses showed that the dot/icm genes, dotB, icmQ, icmS, and icmW are expressed during C. burnetii infection of Vero cells.
Formal Description
Interaction-ID: 32806

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmS

in Vero cells
Comment RT-PCR analyses showed that the dot/icm genes, dotB, icmQ, icmS, and icmW are expressed during C. burnetii infection of Vero cells.
Formal Description
Interaction-ID: 32807

process

Coxiella burnetii infection

increases_expression of

gene/protein

icmW

in Vero cells
Comment Chloramphenicol significantly reduces the capacity of C. burnetii to block the intrinsic death pathway and inhibit host cell apoptosis.
Formal Description
Interaction-ID: 32823

process

Coxiella burnetii infection

decreases_activity of

process

host cell apoptosis