General Information:

Id: 3,521 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: McDonough JA et al.(2012) Coxiella burnetii Secretion Systems Adv. Exp. Med. Biol. 984: 171-197 [PMID: 22711632]

Interaction Information:

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. The dot/icm locus is upregulated in response to infection.
Formal Description
Interaction-ID: 32756

process

Coxiella burnetii infection

increases_activity of

process

T4BSS

during the initial 16 h of infection
Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32763

gene/protein

icmW

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32765

gene/protein

CBU_1651

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32766

gene/protein

icmX

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32767

gene/protein

icmV

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32768

gene/protein

dotaA

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32769

gene/protein

CBU_1647

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32770

gene/protein

icmT

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32771

gene/protein

icmS

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32773

gene/protein

icmD

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32774

gene/protein

icmC

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmS-icmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32775

gene/protein

icmB

affects_activity of

process

T4BSS

Comment The Dot/Icm type IV secretion system has been analysed in C. burnetii in homology to L. pneumophila. Examination of the relative transcript levels concerning the three operons icmW-CBU1651-icmX, icmV-dotA-CBU1647 and icmT-icmSicmD-icmC-icmB-CBU1646 showed an increased transcription of these genes during the initial 16 h of C. burnetii infection of a eukaryotic host cell, and a subsequent drop in transcript levels by 24 h post-infection.
Formal Description
Interaction-ID: 32776

gene/protein

CBU_1646

affects_activity of

process

T4BSS

Comment The regulation of the C. burnetii Dot/Icm system is mediated directly by the response regulator PmrA.
Formal Description
Interaction-ID: 32783

gene/protein

pmrA

increases_activity of

process

T4BSS

Comment The application of an icmL::Tn mutant to infect mammalian host cells results in a complete defect in C. burnetii intracellular growth similar to the effect of chloramphenicol on wild type C. burnetii replication in cultured host cells.
Formal Description
Interaction-ID: 32832

gene/protein

icmL.1

affects_activity of

process

T4BSS

Comment It has been shown by immunoblot analysis that the endogenously-produced effector proteins AnkG and CBU0077 are translocated during C. burnetii infection of host cells.
Formal Description
Interaction-ID: 32834

process

T4BSS

increases_transport of

gene/protein

ankG

Comment It has been shown by immunoblot analysis that the endogenously-produced effector proteins AnkG and CBU0077 are translocated during C. burnetii infection of host cells.
Formal Description
Interaction-ID: 32835

process

T4BSS

increases_transport of

gene/protein

CBU_0077

Comment Concerning the C. burnetii effectors with ankyrin repeats it was shown in a Cya transporter assay that AnkA, AnkB, AnkF and AnkG were translocated in a Dot/Icm-dependent manner.
Formal Description
Interaction-ID: 32838

process

T4BSS

increases_transport of

gene/protein

ankA

shown in a Cya translocation assay
Comment Concerning the C. burnetii effectors with ankyrin repeats it was shown in a Cya transporter assay that AnkA, AnkB, AnkF and AnkG were translocated in a Dot/Icm-dependent manner.
Formal Description
Interaction-ID: 32842

process

T4BSS

increases_transport of

gene/protein

ankB

shown in a Cya translocation assay
Comment Concerning the C. burnetii effectors with ankyrin repeats it was shown in a Cya transporter assay that AnkA, AnkB, AnkF and AnkG were translocated in a Dot/Icm-dependent manner.
Formal Description
Interaction-ID: 32844

process

T4BSS

increases_transport of

gene/protein

ankF

shown in a Cya translocation assay
Comment Concerning the C. burnetii effectors with ankyrin repeats it was shown in a Cya transporter assay that AnkA, AnkB, AnkF and AnkG were translocated in a Dot/Icm-dependent manner.
Formal Description
Interaction-ID: 32845

process

T4BSS

increases_transport of

gene/protein

ankG

shown in a Cya translocation assay
Comment RT-PCR analyses showed that the dot/icm genes, dotB, icmQ, icmS, and icmW are expressed during C. burnetii infection of Vero cells.
Formal Description
Interaction-ID: 35830

gene/protein

icmQ

affects_activity of

process

T4BSS