General Information:

Id: 3,491 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
THP-1 cells, infected with L. pneumophila expressing the indicated CyaA fusion proteins of C. burnetii, strain Nine Mile phase II
article
Reference: Voth DE et al.(2011) The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates J. Bacteriol. 193: 1493-1503 [PMID: 21216993]

Interaction Information:

Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32431

process

T4BSS

increases_transport of

gene/protein

cpeC

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32433

process

T4BSS

increases_transport of

gene/protein

cpeD

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32435

process

T4BSS

increases_transport of

gene/protein

cpeE

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32450

process

T4BSS

increases_transport of

gene/protein

cpeA

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32451

process

T4BSS

increases_transport of

gene/protein

cpeB

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32452

process

T4BSS

increases_transport of

gene/protein

cpeF

into host cell cytosol; shown in CyaA and BlaM translocation assays