General Information:

Id: 3,491
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
THP-1 cells, infected with L. pneumophila expressing the indicated CyaA fusion proteins of C. burnetii, strain Nine Mile phase II
article
Reference: Voth DE et al.(2011) The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates J. Bacteriol. 193: 1493-1503 [PMID: 21216993]

Interaction Information:

Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32431

process

T4BSS

increases_transport of

gene/protein

cpeC

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32433

process

T4BSS

increases_transport of

gene/protein

cpeD

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32435

process

T4BSS

increases_transport of

gene/protein

cpeE

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32450

process

T4BSS

increases_transport of

gene/protein

cpeA

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32451

process

T4BSS

increases_transport of

gene/protein

cpeB

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 32452

process

T4BSS

increases_transport of

gene/protein

cpeF

into host cell cytosol; shown in CyaA and BlaM translocation assays
Comment The expression of the six plasmid effectors genes CpeA-F is temporally regulated, with highest expression observed concomitant with early-log-phase growth (2 and 3 days) and rapid PV expansion.
Formal Description
Interaction-ID: 32461

increases_expression of

gene/protein

cpeA

at early-log-phase growth (2 and 3 days)
Comment The expression of the six plasmid effectors genes CpeA-F is temporally regulated, with highest expression observed concomitant with early-log-phase growth (2 and 3 days) and rapid PV expansion.
Formal Description
Interaction-ID: 32465

increases_expression of

gene/protein

cpeB

at early-log-phase growth (2 and 3 days)
Comment The expression of the six plasmid effectors genes CpeA-F is temporally regulated, with highest expression observed concomitant with early-log-phase growth (2 and 3 days) and rapid PV expansion.
Formal Description
Interaction-ID: 32467

increases_expression of

gene/protein

cpeC

at early-log-phase growth (2 and 3 days)
Comment The expression of the six plasmid effectors genes CpeA-F is temporally regulated, with highest expression observed concomitant with early-log-phase growth (2 and 3 days) and rapid PV expansion.
Formal Description
Interaction-ID: 32468

increases_expression of

gene/protein

cpeD

at early-log-phase growth (2 and 3 days)
Comment The expression of the six plasmid effectors genes CpeA-F is temporally regulated, with highest expression observed concomitant with early-log-phase growth (2 and 3 days) and rapid PV expansion.
Formal Description
Interaction-ID: 32469

increases_expression of

gene/protein

cpeE

at early-log-phase growth (2 and 3 days)
Comment The expression of the six plasmid effectors genes CpeA-F is temporally regulated, with highest expression observed concomitant with early-log-phase growth (2 and 3 days) and rapid PV expansion.
Formal Description
Interaction-ID: 32470

increases_expression of

gene/protein

cpeF

at early-log-phase growth (2 and 3 days)
Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36389

gene/protein

cpeC

is localized in

cellular component

host cell cytosol

shown in CyaA and BlaM translocation assays
Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36390

gene/protein

cpeD

is localized in

cellular component

host cell cytosol

shown in CyaA and BlaM translocation assays
Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36391

gene/protein

cpeE

is localized in

cellular component

host cell cytosol

shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36392

gene/protein

cpeA

is localized in

cellular component

host cell cytosol

shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36393

gene/protein

cpeB

is localized in

cellular component

host cell cytosol

shown in CyaA and BlaM translocation assays
Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36395

gene/protein

cpeF

is localized in

cellular component

host cell cytosol

shown in CyaA and BlaM translocation assays
Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36569

gene/protein

cpeC

is_part_of

organism model

QpH1 plasmid

Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36570

gene/protein

cpeD

is_part_of

organism model

QpH1 plasmid

Comment The CBUA0014 (CpeC), CBUA0015 (CpeD) and CBUA0016 (CpeE) proteins, denoted as Coxiella plasmid effector protein C, D and E are Dot/Icm substrates. They were translocated into the host cell cytosol in a Dot/Icm-dependent manner. CpeC, CpeD and CpeE are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36571

gene/protein

cpeE

is_part_of

organism model

QpH1 plasmid

Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36572

gene/protein

cpeA

is_part_of

organism model

QpH1 plasmid

Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36573

gene/protein

cpeB

is_part_of

organism model

QpH1 plasmid

Comment The following hypothetical proteins were also translocated into the host cell cytosol in a Dot/Icm-dependent manner, CpeA (CBUA0006), CpeB (CBUA0013) and CpeF (CBUA0023). CpeA, CpeB and CpeF are plasmid QpH1 specific.
Formal Description
Interaction-ID: 36574

gene/protein

cpeF

is_part_of

organism model

QpH1 plasmid