General Information:

Id: 3,437
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Sonnleitner E and Haas D(2011) Small RNAs as regulators of primary and secondary metabolism in Pseudomonas species Appl. Microbiol. Biotechnol. 91: 63-79 [PMID: 21607656]

Interaction Information:

Comment Iron excess causes binding of Fe2+ ions to the Fur protein in the cytoplasm, leading to the active form of this transcriptional repressor protein.
Formal Description
Interaction-ID: 31959

environment

high iron level

increases_activity of

gene/protein

fur

in the cytoplasm
Comment Active Fur (Fur-Fe2+) represses the transcription of the sRNA genes prrF1 and prrF2.
Formal Description
Interaction-ID: 31963

gene/protein

fur

decreases_expression of

ncRNA/miRNA

prrF1

Comment Active Fur (Fur-Fe2+) represses the transcription of the sRNA genes prrF1 and prrF2.
Formal Description
Interaction-ID: 31964

gene/protein

fur

decreases_expression of

ncRNA/miRNA

prrF2

Comment Iron excess causes binding of Fe2+ ions to the Fur protein in the cytoplasm, leading to the active form of this transcriptional repressor protein. Low iron levels lead to inactive Fur and to transcription of the sRNAs PrrF1 and PrrF2.
Formal Description
Interaction-ID: 31965

environment

low iron level

decreases_activity of

gene/protein

fur

Comment Iron excess causes binding of Fe2+ ions to the Fur protein in the cytoplasm, leading to the active form of this transcriptional repressor protein. Low iron levels lead to inactive Fur and to transcription of the sRNAs PrrF1 and PrrF2.
Formal Description
Interaction-ID: 31966

environment

low iron level

increases_expression of

ncRNA/miRNA

prrF1

Comment Iron excess causes binding of Fe2+ ions to the Fur protein in the cytoplasm, leading to the active form of this transcriptional repressor protein. Low iron levels lead to inactive Fur and to transcription of the sRNAs PrrF1 and PrrF2.
Formal Description
Interaction-ID: 31968

environment

low iron level

increases_expression of

ncRNA/miRNA

prrF2

Comment In P. aeruginosa, the PrrF sRNAs translationally repress the expression of sodB, katA, bfrB and other genes encoding iron-containing proteins, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 31969

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

sodB

Comment In P. aeruginosa, the PrrF sRNAs translationally repress the expression of sodB, katA, bfrB and other genes encoding iron-containing proteins, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 31970

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

sodB

Comment In P. aeruginosa, the PrrF sRNAs translationally repress the expression of sodB, katA, bfrB and other genes encoding iron-containing proteins, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 31971

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

katA

Drugbank entries Show/Hide entries for katA
Comment In P. aeruginosa, the PrrF sRNAs translationally repress the expression of sodB, katA, bfrB and other genes encoding iron-containing proteins, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 31972

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

katA

Drugbank entries Show/Hide entries for katA
Comment In P. aeruginosa, the PrrF sRNAs translationally repress the expression of sodB, katA, bfrB and other genes encoding iron-containing proteins, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 31973

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

bfrB

Comment In P. aeruginosa, the PrrF sRNAs translationally repress the expression of sodB, katA, bfrB and other genes encoding iron-containing proteins, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 31974

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

bfrB

Comment A delta-prrF1,2 mutant increased the degradation of anthranilate. As anthranilate is a precursor of the Pseudomonas quinolone signal (PQS), this mutant produces a much reduced amount of PQS.
Formal Description
Interaction-ID: 31975

ncRNA/miRNA

prrF1

affects_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

Comment A delta-prrF1,2 mutant increased the degradation of anthranilate. As anthranilate is a precursor of the Pseudomonas quinolone signal (PQS), this mutant produces a much reduced amount of PQS.
Formal Description
Interaction-ID: 31977

ncRNA/miRNA

prrF2

affects_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

Comment The transcriptional activator ANR is a dimeric iron-sulphur protein that is active under conditions of low oxygen tension.
Formal Description
Interaction-ID: 31997

environment

low oxygen level

increases_activity of

gene/protein

anr

Comment The phrS sRNA of P. aeruginosa is produced abundantly in dense P. aeruginosa cultures when oxygen becomes scarce.
Formal Description
Interaction-ID: 31998

environment

low oxygen level

increases_expression of

ncRNA/miRNA

phrS

Comment In P. aeruginosa the transcriptional activator ANR positively controls the phrS sRNA. An anr-negative mutant is devoid of phrS expression.
Formal Description
Interaction-ID: 31999

gene/protein

anr

increases_expression of

ncRNA/miRNA

phrS

Comment The transcriptional activator ANR is a dimeric iron-sulphur protein that is active under conditions of low oxygen tension.
Formal Description
Interaction-ID: 32000

environment

high oxygen level

decreases_activity of

gene/protein

anr

Comment PhrS sRNA has been analysed as a positive regulator of PQS synthesis. The mechanism by which PhrS sRNA activates PQS synthesis is complex and involves the enhanced expression of the PqsR protein, a positive regulator of PQS synthesis.
Formal Description
Interaction-ID: 32001

ncRNA/miRNA

phrS

increases_quantity of

gene/protein

mvfR

Comment PhrS sRNA has been analysed as a positive regulator of PQS synthesis. The mechanism by which PhrS sRNA activates PQS synthesis is complex and involves the enhanced expression of the PqsR protein, a positive regulator of PQS synthesis.
Formal Description
Interaction-ID: 32028

ncRNA/miRNA

phrS

increases_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

Comment The response to changing carbon and nitrogen sources is maintained by the two-component system CbrA/CbrB. Preferred carbon sources cause an inhibition of CbrA/CbrB activity. The response regulator CbrB activates the transcription of the sRNA gene crcZ in the absence of preferred growth substrates.
Formal Description
Interaction-ID: 32030

gene/protein

cbrA

increases_activity of

gene/protein

cbrB

Comment The response to changing carbon and nitrogen sources is maintained by the two-component system CbrA/CbrB. Preferred carbon sources cause an inhibition of CbrA/CbrB activity. The response regulator CbrB activates the transcription of the sRNA gene crcZ in the absence of preferred growth substrates.
Formal Description
Interaction-ID: 32032

gene/protein

cbrA

affects_activity of

Comment The response to changing carbon and nitrogen sources is maintained by the two-component system CbrA/CbrB. Preferred carbon sources cause an inhibition of CbrA/CbrB activity. The response regulator CbrB activates the transcription of the sRNA gene crcZ in the absence of preferred growth substrates.
Formal Description
Interaction-ID: 32033

gene/protein

cbrB

affects_activity of

Comment The response to changing carbon and nitrogen sources is maintained by the two-component system CbrA/CbrB. Preferred carbon sources cause an inhibition of CbrA/CbrB activity. The response regulator CbrB activates the transcription of the sRNA gene crcZ in the absence of preferred growth substrates.
Formal Description
Interaction-ID: 32046

gene/protein

cbrB

increases_expression of

ncRNA/miRNA

crcZ

in the absence of preferred growth substrates
Comment The sRNA CrcZ inhibits the function of the catabolite repression control protein Crc by sequestration of the protein.
Formal Description
Interaction-ID: 32047

ncRNA/miRNA

crcZ

decreases_activity of

gene/protein

crc

Comment The sRNA CrcZ inhibits the function of the catabolite repression control protein Crc by sequestration of the protein, thus allowing the catabolic pathways for less preferred substrates to become functional.
Formal Description
Interaction-ID: 32048

gene/protein

crc

affects_activity of

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of PA4880, a putative bacterioferritin, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40811

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

PA4880

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of PA4880, a putative bacterioferritin, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40814

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

PA4880

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of sdhCDAB (succinate dehydrogenase) probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40815

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

sdhC

Drugbank entries Show/Hide entries for sdhC
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of sdhCDAB (succinate dehydrogenase) probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40818

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

sdhC

Drugbank entries Show/Hide entries for sdhC
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of sdhCDAB (succinate dehydrogenase) probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40819

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

sdhD

Drugbank entries Show/Hide entries for sdhD
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of sdhCDAB (succinate dehydrogenase) probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40820

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

sdhD

Drugbank entries Show/Hide entries for sdhD
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of sdhCDAB (succinate dehydrogenase) probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40821

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

sdhA

Drugbank entries Show/Hide entries for sdhA
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of sdhCDAB (succinate dehydrogenase) probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40824

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

sdhA

Drugbank entries Show/Hide entries for sdhA
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of sdhCDAB (succinate dehydrogenase) probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40825

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

sdhB

Drugbank entries Show/Hide entries for sdhB
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of sdhCDAB (succinate dehydrogenase) probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40826

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

sdhB

Drugbank entries Show/Hide entries for sdhB
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the aconitases acnA and acnB probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40828

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

acnA

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the aconitases acnA and acnB probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40832

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

acnA

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the aconitases acnA and acnB probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40833

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

acnB

Drugbank entries Show/Hide entries for acnB
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the aconitases acnA and acnB probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40835

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

acnB

Drugbank entries Show/Hide entries for acnB
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of prpB, a putative isocitrate lyase , probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40836

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

prpB

Drugbank entries Show/Hide entries for prpB
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of prpB, a putative isocitrate lyase , probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40839

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

prpB

Drugbank entries Show/Hide entries for prpB
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes antABC, involved in anthranilate degradation.
Formal Description
Interaction-ID: 40840

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

antA

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes antABC, involved in anthranilate degradation.
Formal Description
Interaction-ID: 40843

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

antA

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes antABC, involved in anthranilate degradation.
Formal Description
Interaction-ID: 40844

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

antB

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes antABC, involved in anthranilate degradation.
Formal Description
Interaction-ID: 40848

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

antB

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes antABC, involved in anthranilate degradation.
Formal Description
Interaction-ID: 40849

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

antC

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes antABC, involved in anthranilate degradation.
Formal Description
Interaction-ID: 40850

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

antC

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes catABC, involved in catechol degradation, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40851

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

catA

Drugbank entries Show/Hide entries for catA
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes catABC, involved in catechol degradation, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40852

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

catA

Drugbank entries Show/Hide entries for catA
Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes catABC, involved in catechol degradation, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40853

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

catB

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes catABC, involved in catechol degradation, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40854

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

catB

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes catABC, involved in catechol degradation, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40855

ncRNA/miRNA

prrF1

decreases_quantity of

gene/protein

catC

Comment In P. aeruginosa, the sRNAs PrrF1 and PrrF2 translationally repress the expression of the genes catABC, involved in catechol degradation, probably via a base-pairing mechanism.
Formal Description
Interaction-ID: 40857

ncRNA/miRNA

prrF2

decreases_quantity of

gene/protein

catC