General Information:

Id: 3,419 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
MDCK or Caco-2 cells, infected with P. aeruginosa strain PAO1
article
Reference: Okuda J et al.(2010) Translocation of Pseudomonas aeruginosa from the intestinal tract is mediated by the binding of ExoS to an Na,K-ATPase regulator, FXYD3 Infect. Immun. 78: 4511-4522 [PMID: 20805335]

Interaction Information:

Comment A greater fraction of PAO1 bacteria penetrated the MDCK cell monolayers through the paracellular spaces than by the direct invasion of the cells. The paracellular spaces between epithelial cells are sealed by tight junctions (TJs), which establish the epithelial barrier to prevent bacterial penetration from the intestine into the bloodstream. ExoS is necessary for penetration of P. aeruginosa through epithelial cell monolayers in vitro, the penetration capacity of the delta-exoS strain is strongly attenuated.
Formal Description
Interaction-ID: 31766

gene/protein

exoS

decreases_activity of

in MDCK cell monolayers and Caco-2 colon epithelial cells