General Information:

Id: 3,415 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000195 CACO-2 cell monolayers, infected with P. aeruginosa strain PAO1
Reference: Okuda J et al.(2011) Degradation of interleukin 8 by the serine protease MucD of Pseudomonas aeruginosa J. Infect. Chemother. 17: 782-792 [PMID: 21626303]

Interaction Information:

Comment Significant IL-8 degradation in overnight cultures was detected in the supernatant of the wild-type strain. Experiments with serine protease inhibitors, exhibited a significant inhibitory effect on IL-8 degradation. Experiments using the knock-out strains of two possible serine protease candidate genes (delta-PA3535 and delta-mucD) revealed that only MucD was associated with the degradation of IL-.
Formal Description
Interaction-ID: 31701



decreases_quantity of



in the culture medium of Caco-2 monolayers