General Information:

Id: 3,359 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Calu-3 cells, infected with P. aeruginosa strain PAO1
article
Reference: Bucior I et al.(2012) Pseudomonas aeruginosa pili and flagella mediate distinct binding and signaling events at the apical and basolateral surface of airway epithelium PLoS Pathog. 8 [PMID: 22496644]

Interaction Information:

Comment Flagella-mediated bacterial entry at the basolateral surface and Tfp-mediated entry at the apical surface of polarized epithelium involve PI3K/Akt activation.
Formal Description
Interaction-ID: 30822

cellular component

flagellum

increases_activity of

at the basolateral surface surface of polarized epithelium
Comment Flagella-mediated bacterial entry at the basolateral surface and Tfp-mediated entry at the apical surface of polarized epithelium involve PI3K/Akt activation.
Formal Description
Interaction-ID: 30830

cellular component

type IV pilus

increases_activity of

at the apical surface of polarized epithelial cells
Comment The binding of flagella to HS chains of HSPGs at the BL surface results in activation of EGFR and subsequent activation of PI3K/Akt.
Formal Description
Interaction-ID: 31587

gene/protein

EGFR

increases_activity of

at the basolateral surface surface of polarized epithelium
Drugbank entries Show/Hide entries for EGFR