General Information:

Id: 3,348 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
HeLa cell, infected with P. aeruginosa strain PAO1
article
Reference: Sana TG et al.(2012) The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells J. Biol. Chem. 287 [PMID: 22665491]

Interaction Information:

Comment H2-T6SS system stimulates internalization of P. aeruginosa into HeLa cells.
Formal Description
Interaction-ID: 30764

process

P. aeruginosa infection

increases_activity of

process

T6SS-HSI-2

analysed by internalization of P. aeruginosa into HeLa cells
Comment P. aeruginosa binding to polarized epithelial cells activates a central host signalling molecule, phosphatidylinositol 3-kinase (PI3K), which is required for PIP3 synthesis and for activation of a downstream effector, the protein kinase B/Akt (Akt). Akt phosphorylation upon bacterial invasion of polarized epithelial cells is dependent on H2-T6SS.
Formal Description
Interaction-ID: 30765

process

T6SS-HSI-2

increases_activity of

analysed by internalization of P. aeruginosa into Calu-3 cells
Comment P. aeruginosa binding to polarized epithelial cells activates a central host signalling molecule, phosphatidylinositol 3-kinase (PI3K), which is required for PIP3 synthesis and for activation of a downstream effector, the protein kinase B/Akt (Akt). Akt phosphorylation upon bacterial invasion of polarized epithelial cells is dependent on H2-T6SS.
Formal Description
Interaction-ID: 30835

process

T6SS-HSI-2

increases_activity of

analysed by internalization of P. aeruginosa into Calu-3 cells