General Information:

Id: 3,307 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
mouse monocyte/macrophage cell line J774A.1 or mouse bronchoalveolar lavage (BAL) fluid, infected with P. aeruginosa strain PA14
article
Reference: Kim K et al.(2010) HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-kappaB pathway Immunology 129: 578-588 [PMID: 20102415]

Interaction Information:

Comment HHQ (4-hydroxy-2-heptylquinoline) and PQS (2-heptyl-3,4-dihydroxyquinoline, pseudomonas quinolone signal) suppress the expression of the innate cytokines TNF-alpha and IL-6.
Formal Description
Interaction-ID: 30373

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

decreases_expression of

gene/protein

TNF

in J774A.1 and primary BAL cells
Drugbank entries Show/Hide entries for TNF
Comment HHQ (4-hydroxy-2-heptylquinoline) and PQS (2-heptyl-3,4-dihydroxyquinoline, pseudomonas quinolone signal) suppress the expression of the innate cytokines TNF-alpha and IL-6.
Formal Description
Interaction-ID: 30378

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

decreases_expression of

gene/protein

TNF

in J774A.1 and primary BAL cells
Drugbank entries Show/Hide entries for TNF