General Information:

Id: 3,231 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Mikkelsen H et al.(2011) Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa Environ. Microbiol. 13: 1666-1681 [PMID: 21554516]

Interaction Information:

Comment In P. aeruginosa, the flagellum is recognized as a central component in the biofilm formation process, since it provides the mobility needed to actively approach a surface.
Formal Description
Interaction-ID: 29785

cellular component

flagellum

increases_activity of

Comment Type IV pili are also central factors in surface attachment and colonization.
Formal Description
Interaction-ID: 29786

cellular component

type IV pilus

increases_activity of

Comment A novel set of extracellular appendages in P. aeruginosa were named Cup fimbriae. Five fimbrial (cup) gene clusters have been identified to date, termed cupA-E. The Cup fimbriae have all been shown to contribute to biofilm formation or to alter the adhesive properties of the strain that expresses them.
Formal Description
Interaction-ID: 29787

process

CupA fimbriae assembly

increases_activity of

Comment A novel set of extracellular appendages in P. aeruginosa were named Cup fimbriae. Five fimbrial (cup) gene clusters have been identified to date, termed cupA-E. The Cup fimbriae have all been shown to contribute to biofilm formation or to alter the adhesive properties of the strain that expresses them.
Formal Description
Interaction-ID: 29788

process

CupB fimbriae assembly

increases_activity of

Comment A novel set of extracellular appendages in P. aeruginosa were named Cup fimbriae. Five fimbrial (cup) gene clusters have been identified to date, termed cupA-E. The Cup fimbriae have all been shown to contribute to biofilm formation or to alter the adhesive properties of the strain that expresses them.
Formal Description
Interaction-ID: 29789

process

CupC fimbriae assembly

increases_activity of

Comment A novel set of extracellular appendages in P. aeruginosa were named Cup fimbriae. Five fimbrial (cup) gene clusters have been identified to date, termed cupA-E. The Cup fimbriae have all been shown to contribute to biofilm formation or to alter the adhesive properties of the strain that expresses them.
Formal Description
Interaction-ID: 29790

process

CupD fimbriae assembly

increases_activity of

Comment A novel set of extracellular appendages in P. aeruginosa were named Cup fimbriae. Five fimbrial (cup) gene clusters have been identified to date, termed cupA-E. The Cup fimbriae have all been shown to contribute to biofilm formation or to alter the adhesive properties of the strain that expresses them.
Formal Description
Interaction-ID: 29791

process

CupE fimbriae assembly

increases_activity of

Comment There are three TCSs, BfiSR (biofilm initiation), BfmSR (biofilm maturation) and MifSR (microcolony formation), that are phosphorylated at distinct stages of biofilm formation, but not in planktonic cells. These signalling systems appear to act as checkpoints for the progression of biofilm formation.
Formal Description
Interaction-ID: 30058

gene/protein

bfiR

increases_activity of

biofilm initiation
Comment There are three TCSs, BfiSR (biofilm initiation), BfmSR (biofilm maturation) and MifSR (microcolony formation), that are phosphorylated at distinct stages of biofilm formation, but not in planktonic cells. These signalling systems appear to act as checkpoints for the progression of biofilm formation.
Formal Description
Interaction-ID: 30060

gene/protein

bfmR

increases_activity of

biofilm maturation
Comment There are three TCSs, BfiSR (biofilm initiation), BfmSR (biofilm maturation) and MifSR (microcolony formation), that are phosphorylated at distinct stages of biofilm formation, but not in planktonic cells. These signalling systems appear to act as checkpoints for the progression of biofilm formation.
Formal Description
Interaction-ID: 30063

gene/protein

mifR

increases_activity of

microcolony formation