General Information:

Id: 3,183 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Reference: Hao Y et al.(2012) Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2 Cell. Microbiol. 14: 401-415 [PMID: 22103442]

Interaction Information:

Comment MUC5B and MUC5AC are two of the major airway secretory mucins. The levels of both mucins are elevated in secretions from diseased airways, with MUC5B being the most abundant mucin in the sputum of CF and COPD patients (cited information).
Formal Description
Interaction-ID: 43315


P. aeruginosa infection, chronic

increases_activity of


mucus secretion

in CF patients