General Information:

Id: 3,183 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
article/cited
Reference: Hao Y et al.(2012) Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2 Cell. Microbiol. 14: 401-415 [PMID: 22103442]

Interaction Information:

Comment Pyocyanin in concentrations of 100 mM has been detected in pulmonary secretions of bronchiectasis patients. It has been shown that a majority of CF isolates of Pseudomonas aeruginosa overproduced PCN (pyocyanin) (cited information).
Formal Description
Interaction-ID: 29193

process

P. aeruginosa infection, chronic

increases_quantity of

drug/chemical compound

Pyocyanine

in CF patients
Comment MUC5B and MUC5AC are two of the major airway secretory mucins. The levels of both mucins are elevated in secretions from diseased airways, with MUC5B being the most abundant mucin in the sputum of CF and COPD patients (cited information).
Formal Description
Interaction-ID: 29206

process

P. aeruginosa infection, chronic

increases_quantity of

gene/protein

MUC5B

in CF patients; the most abundant mucin in the sputum of CF
Comment MUC5B and MUC5AC are two of the major airway secretory mucins. The levels of both mucins are elevated in secretions from diseased airways, with MUC5B being the most abundant mucin in the sputum of CF and COPD patients (cited information).
Formal Description
Interaction-ID: 29213

process

P. aeruginosa infection, chronic

increases_quantity of

gene/protein

MUC5AC

in CF patients
Comment MUC5B and MUC5AC are two of the major airway secretory mucins. The levels of both mucins are elevated in secretions from diseased airways, with MUC5B being the most abundant mucin in the sputum of CF and COPD patients (cited information).
Formal Description
Interaction-ID: 43315

process

P. aeruginosa infection, chronic

increases_activity of

process

mucus secretion

in CF patients