General Information:

Id: 3,140 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Engel J and Eran Y(2011) Subversion of mucosal barrier polarity by pseudomonas aeruginosa. Front Microbiol 2: 114 [PMID: 21747810]

Interaction Information:

Comment The results confirm that the ADPRT domain of ExoS is sufficient to disrupt epithelial barrier integrity. PAK strains expressing ExoS disrupted ZO-1, occludin, and ezrin localization, decreased membrane-associated occludin, and blocked ezrin phosphorylation as would be predicted from ADP ribosylation of ezrin.
Formal Description
Interaction-ID: 28964

gene/protein

exoS

decreases_activity of

gene/protein

EZR