General Information:

Id: 3,140 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Engel J and Eran Y(2011) Subversion of mucosal barrier polarity by pseudomonas aeruginosa. Front Microbiol 2: 114 [PMID: 21747810]

Interaction Information:

Comment Out of the four known P. aeruginosa T3SS effectors proteins, ExoS and ExoT are logical candidates for interfering with cellular polarity and disrupting cell junction integrity.
Formal Description
Interaction-ID: 28929

gene/protein

exoT

decreases_activity of

Comment Out of the four known P. aeruginosa T3SS effectors proteins, ExoS and ExoT are logical candidates for interfering with cellular polarity and disrupting cell junction integrity.
Formal Description
Interaction-ID: 28930

gene/protein

exoT

decreases_activity of

Comment The GAP domains of both ExoT and ExoS inactivate the RhoA family GTPases, Cdc42, Rac1, and RhoA.
Formal Description
Interaction-ID: 28959

gene/protein

exoT

decreases_activity of

gene/protein

CDC42

Drugbank entries Show/Hide entries for CDC42
Comment The GAP domains of both ExoT and ExoS inactivate the RhoA family GTPases, Cdc42, Rac1, and RhoA.
Formal Description
Interaction-ID: 28960

gene/protein

exoT

decreases_activity of

gene/protein

RAC1

Drugbank entries Show/Hide entries for RAC1
Comment The GAP domains of both ExoT and ExoS inactivate the RhoA family GTPases, Cdc42, Rac1, and RhoA.
Formal Description
Interaction-ID: 28961

gene/protein

exoT

decreases_activity of

gene/protein

RHOA

Drugbank entries Show/Hide entries for RHOA