General Information:

Id: 3,140 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Engel J and Eran Y(2011) Subversion of mucosal barrier polarity by pseudomonas aeruginosa. Front Microbiol 2: 114 [PMID: 21747810]

Interaction Information:

Comment Out of the four known P. aeruginosa T3SS effectors proteins, ExoS and ExoT are logical candidates for interfering with cellular polarity and disrupting cell junction integrity.
Formal Description
Interaction-ID: 28926

gene/protein

exoS

decreases_activity of

Comment Out of the four known P. aeruginosa T3SS effectors proteins, ExoS and ExoT are logical candidates for interfering with cellular polarity and disrupting cell junction integrity.
Formal Description
Interaction-ID: 28928

gene/protein

exoS

decreases_activity of

Comment The GAP domains of both ExoT and ExoS inactivate the RhoA family GTPases, Cdc42, Rac1, and RhoA.
Formal Description
Interaction-ID: 28956

gene/protein

exoS

decreases_activity of

gene/protein

CDC42

Drugbank entries Show/Hide entries for CDC42
Comment The GAP domains of both ExoT and ExoS inactivate the RhoA family GTPases, Cdc42, Rac1, and RhoA.
Formal Description
Interaction-ID: 28957

gene/protein

exoS

decreases_activity of

gene/protein

RAC1

Drugbank entries Show/Hide entries for RAC1
Comment The GAP domains of both ExoT and ExoS inactivate the RhoA family GTPases, Cdc42, Rac1, and RhoA.
Formal Description
Interaction-ID: 28958

gene/protein

exoS

decreases_activity of

gene/protein

RHOA

Drugbank entries Show/Hide entries for RHOA
Comment The results confirm that the ADPRT domain of ExoS is sufficient to disrupt epithelial barrier integrity. PAK strains expressing ExoS disrupted ZO-1, occludin, and ezrin localization, decreased membrane-associated occludin, and blocked ezrin phosphorylation as would be predicted from ADP ribosylation of ezrin.
Formal Description
Interaction-ID: 28962

gene/protein

exoS

decreases_activity of

gene/protein

TJP1

Comment The results confirm that the ADPRT domain of ExoS is sufficient to disrupt epithelial barrier integrity. PAK strains expressing ExoS disrupted ZO-1, occludin, and ezrin localization, decreased membrane-associated occludin, and blocked ezrin phosphorylation as would be predicted from ADP ribosylation of ezrin.
Formal Description
Interaction-ID: 28963

gene/protein

exoS

decreases_activity of

gene/protein

OCLN

Comment The results confirm that the ADPRT domain of ExoS is sufficient to disrupt epithelial barrier integrity. PAK strains expressing ExoS disrupted ZO-1, occludin, and ezrin localization, decreased membrane-associated occludin, and blocked ezrin phosphorylation as would be predicted from ADP ribosylation of ezrin.
Formal Description
Interaction-ID: 28964

gene/protein

exoS

decreases_activity of

gene/protein

EZR