General Information:

Id: 3,140 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Reference: Engel J and Eran Y(2011) Subversion of mucosal barrier polarity by pseudomonas aeruginosa. Front Microbiol 2: 114 [PMID: 21747810]

Interaction Information:

Comment P. aeruginosa transforms apical into basolateral membrane, creating a local microenvironment that facilitates its colonization and entry into to the mucosal barrier. In polarized monolayers, P. aeruginosa binds near cell-cell junctions, where it activates and recruits PI3K to the apical surface, leading to a remarkable remodeling of the apical membrane in which protrusions enriched for PIP3 and actin form at the apical surface at the site of bacterial binding.
Formal Description
Interaction-ID: 28922


P. aeruginosa infection

increases_activity of

protrusions are deficient in apical markers and contain basolateral markers