General Information:

Id: 3,140 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Reference: Engel J and Eran Y(2011) Subversion of mucosal barrier polarity by pseudomonas aeruginosa. Front Microbiol 2: 114 [PMID: 21747810]

Interaction Information:

Comment At the basolateral surface, the sulfation of heparan sulfate (HS) chains of HSPGs (heparan sulfate proteoglycans) was found to be critical for P. aeruginosa binding, cytotoxicity, and invasion. In incompletely polarized epithelium, HSPG abundance was increased at the apical surface, explaining at least in part the increased susceptibility of injured epithelium to P. aeruginosa colonization and damage.
Formal Description
Interaction-ID: 28919

cellular component

heparan sulfate proteoglycans, HSPGs

increases_activity of


P. aeruginosa infection

at the basolateral surface