General Information:

Id: 3,118 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
airway epithelial cells, infected with P. aeruginosa strain PA14
Reference: Bomberger JM et al.(2009) Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. PLoS Pathog. 5 [PMID: 19360133]

Interaction Information:

Comment Airway epithelial cells treated with lysed OMV (outer membrane vesicles) showed a dramatic reduction in the ability of the Cif toxin to reduce apical membrane CFTR, as compared to cells treated with intact OMV. Therefore, OMV-mediated delivery of virulence factors to airway epithelial cells increases the efficacy of these virulence factors in altering host cell physiology.
Formal Description
Interaction-ID: 28692


bacterial membrane vesicle fusion with host cell membrane

increases_activity of


P. aeruginosa infection